- Meeting: 82nd
- First Meeting: 1926
- Series Record:
Notre Dame leads, 42-34-5
- Last Year: USC won 34-27
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Year-by-Year Results
Overall: ND leads 42-34-5; Home: ND leads 23-13-1; Away: USC leads 21-17-4; Neutral: ND leads 2-0-0
Notes: Recaps for the last 15 games are available by clicking on the year. Ranks column lists Notre Dame's AP ranking at the time of the game followed by USC's AP ranking at the time of the game (since AP poll debuted in 1936).
| SITE | YEAR | RANKS | W/L | ND | USC |
| Memorial Coliseum | 1926 | | W | 13 | 12 |
| Soldier Field (Chicago) | 1927 | | W | 7 | 6 |
| Memorial Coliseum | 1928 | | L | 14 | 27 |
| Soldier Field (Chicago) | 1929 | | W | 13 | 12 |
| Memorial Coliseum | 1930 | | W | 27 | 0 |
| Notre Dame Stadium | 1931 | | L | 14 | 16 |
| Memorial Coliseum | 1932 | | L | 0 | 13 |
| Notre Dame Stadium | 1933 | | L | 0 | 19 |
| Memorial Coliseum | 1934 | | W | 14 | 0 |
| Notre Dame Stadium | 1935 | | W | 20 | 13 |
| Memorial Coliseum | 1936 | 9- | T | 13 | 13 |
| Notre Dame Stadium | 1937 | 9- | W | 13 | 6 |
| Memorial Coliseum | 1938 | 1-8 | L | 0 | 13 |
| Notre Dame Stadium | 1939 | 7-4 | L | 12 | 20 |
| Memorial Coliseum | 1940 | | W | 10 | 6 |
| Notre Dame Stadium | 1941 | 4- | W | 20 | 18 |
| Memorial Coliseum | 1942 | 8-14 | W | 13 | 0 |
| Notre Dame Stadium | 1946 | 2-16 | W | 26 | 6 |
| Memorial Coliseum | 1947 | 1-3 | W | 38 | 7 |
| Memorial Coliseum | 1948 | 2- | T | 14 | 14 |
| Notre Dame Stadium | 1949 | 1-17 | W | 32 | 0 |
| Memorial Coliseum | 1950 | | L | 7 | 9 |
| Memorial Coliseum | 1951 | -20 | W | 19 | 12 |
| Notre Dame Stadium | 1952 | 7-2 | W | 9 | 0 |
| Memorial Coliseum | 1953 | 2-20 | W | 48 | 14 |
| Notre Dame Stadium | 1954 | 4-17 | W | 23 | 17 |
| Memorial Coliseum | 1955 | 5- | L | 20 | 42 |
| Memorial Coliseum | 1956 | -17 | L | 20 | 28 |
| Notre Dame Stadium | 1957 | 12- | W | 40 | 12 |
| Memorial Coliseum | 1958 | 18- | W | 20 | 13 |
| Notre Dame Stadium | 1959 | -7 | W | 16 | 6 |
| Memorial Coliseum | 1960 | | W | 17 | 0 |
| Notre Dame Stadium | 1961 | 8- | W | 30 | 0 |
| Memorial Coliseum | 1962 | -1 | L | 0 | 25 |
| Notre Dame Stadium | 1963 | -7 | W | 17 | 14 |
| Memorial Coliseum | 1964 | 1- | L | 17 | 20 |
| Notre Dame Stadium | 1965 | 7-4 | W | 28 | 7 |
| Memorial Coliseum | 1966 | 1-10 | W | 51 | 0 |
| Notre Dame Stadium | 1967 | 5-1 | L | 7 | 24 |
| Memorial Coliseum | 1968 | 9-2 | T | 21 | 21 |
| Notre Dame Stadium | 1969 | 11-3 | T | 14 | 14 |
| Memorial Coliseum | 1970 | 4- | L | 28 | 38 |
| Notre Dame Stadium | 1971 | 6- | L | 14 | 28 |
| Memorial Coliseum | 1972 | 10-1 | L | 23 | 45 |
| Notre Dame Stadium | 1973 | 8-6 | W | 23 | 14 |
| Memorial Coliseum | 1974 | 5-6 | L | 24 | 55 |
| Notre Dame Stadium | 1975 | 14-3 | L | 17 | 24 |
| Memorial Coliseum | 1976 | 13-3 | L | 13 | 17 |
| Notre Dame Stadium | 1977 | 11-5 | W | 49 | 19 |
| Memorial Coliseum | 1978 | 8-3 | L | 25 | 27 |
| Notre Dame Stadium | 1979 | 9-4 | L | 23 | 42 |
| Memorial Coliseum | 1980 | 2-17 | L | 3 | 20 |
| Notre Dame Stadium | 1981 | -5 | L | 7 | 14 |
| Memorial Coliseum | 1982 | -17 | L | 13 | 17 |
| Notre Dame Stadium | 1983 | | W | 27 | 6 |
| Memorial Coliseum | 1984 | -14 | W | 19 | 7 |
| Notre Dame Stadium | 1985 | | W | 37 | 3 |
| Memorial Coliseum | 1986 | -17 | W | 38 | 37 |
| Notre Dame Stadium | 1987 | 10- | W | 26 | 15 |
| Memorial Coliseum | 1988 | 1-2 | W | 27 | 10 |
| Notre Dame Stadium | 1989 | 1-9 | W | 28 | 24 |
| Memorial Coliseum | 1990 | 7-18 | W | 10 | 6 |
| Notre Dame Stadium | 1991 | 5- | W | 24 | 20 |
| Memorial Coliseum | 1992 | 5-19 | W | 31 | 23 |
| Notre Dame Stadium | 1993 | 2- | W | 31 | 13 |
| Memorial Coliseum | 1994 | -17 | T | 17 | 17 |
| Notre Dame Stadium | 1995 | 17-5 | W | 38 | 10 |
| Memorial Coliseum | 1996 | 10- | L (ot) | 20 | 27 |
| Notre Dame Stadium | 1997 | | L | 17 | 20 |
| Memorial Coliseum | 1998 | 9- | L | 0 | 10 |
| Notre Dame Stadium | 1999 | | W | 25 | 24 |
| Memorial Coliseum | 2000 | 11- | W | 38 | 21 |
| Notre Dame Stadium | 2001 | | W | 27 | 16 |
| Memorial Coliseum | 2002 | 7-6 | L | 13 | 44 |
| Notre Dame Stadium | 2003 | -5 | L | 14 | 45 |
| Memorial Coliseum | 2004 | -1 | L | 10 | 41 |
| Notre Dame Stadium | 2005 | 9-1 | L | 31 | 34 |
| Memorial Coliseum | 2006 | 6-3 | L | 24 | 44 |
| Notre Dame Stadium | 2007 | -13 | L | 0 | 38 |
| Memorial Coliseum | 2008 | -5 | L | 3 | 38 |
| Notre Dame Stadium | 2009 | 25-6 | L | 27 | 34 |
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