| Day | Date | Opponent | Location | TV | Outcome/Time |
| Sat | 10/07/2000 | vs. Minnesota (Hall of Fame Game) | St. Paul, Minn.
(XCel Energy Center) | | L, 7-3
Recap | Stats | Archived Audio |
| Fri | 10/13/2000 | vs. Boston College(Maverick Shootout) | Omaha, Neb. | | L, 4-1
Recap | Stats | Archived Audio |
| Sat | 10/14/2000 | vs. Nebraska Omaha or Niagara | Omaha, Neb. | | T, 3-3
Recap | Stats | Archived Audio |
| Tue | 10/17/2000 | WAYNE STATE | Joyce Center | | W, 2-1 ot
Recap | Archived Audio | Live Box Score |
| Fri | 10/20/2000 | NORTHEASTERN | Joyce Center | | W, 6-4
Recap | Stats | Archived Audio | Live Box Score |
| Sat | 10/21/2000 | NORTHEASTERN | Joyce Center | | L, 5-3
Recap | Archived Audio | Live Box Score |
| Thu | 10/26/2000 | *MICHIGAN STATE | Joyce Center | | L, 5-1
Recap | Stats | Archived Audio | Live Box Score |
| Fri | 10/27/2000 | *MICHIGAN STATE | Joyce Center | | L, 3-2
Recap | Stats | Archived Audio | Live Box Score |
| Fri | 11/03/2000 | *at Miami | Oxford, Ohio | | W, 5-2
Recap | Stats | Archived Audio |
| Sat | 11/04/2000 | *at Miami | Oxford, Ohio | | T, 1-1
Recap | Archived Audio |
| Fri | 11/10/2000 | BOSTON COLLEGE | Joyce Center | | L, 5-3
Recap | Stats | Live Box Score |
| Fri | 11/24/2000 | *NORTHERN MICHIGAN | Joyce Center | | L, 3-1
Recap | Stats | Archived Audio | Live Box Score |
| Sat | 11/25/2000 | *NORTHERN MICHIGAN | Joyce Center | | T, 3-3
Recap | Archived Audio | Live Box Score |
| Fri | 12/01/2000 | at Lake Superior State | Sault Ste. Marie, Mich. | | L, 2-1
Recap | Stats | Archived Audio |
| Sat | 12/02/2000 | at Lake Superior State | Sault Ste. Marie, Mich. | | L, 4-1
Recap | Stats | Archived Audio |
| Fri | 12/08/2000 | *MIAMI | Joyce Center | | L, 5-2
Recap | Stats | Archived Audio | Live Box Score |
| Sat | 12/09/2000 | *MIAMI | Joyce Center | | L, 4-1
Recap | Stats | Live Box Score |
| Tue | 12/19/2000 | *Nebraska | Omaha, Neb. | | L, 1-0
Recap | Stats | Archived Audio |
| Wed | 12/20/2000 | *Nebraska | Omaha, Neb. | | W, 7-3
Recap | Stats | Archived Audio |
| Fri | 12/29/2000 | vs. St. Lawrence (RPI Christmas Tournament) | Troy, N.Y. | | L, 6-3
Recap | Stats | Archived Audio |
| Sat | 12/30/2000 | Rensselaer | Troy, N.Y. | | L, 6-2
Recap | Stats | Archived Audio |
| Fri | 01/05/2001 | *FERRIS STATE | Joyce Center | | L, 4-2
Recap | Stats | Archived Audio | Live Box Score |
| Sat | 01/06/2001 | *FERRIS STATE | Joyce Center | | L, 3-2 ot
Recap | Stats | Archived Audio | Live Box Score |
| Fri | 01/12/2001 | *WESTERN MICHIGAN | Joyce Center | | W, 4-1
Recap | Stats | Archived Audio | Live Box Score |
| Sat | 01/13/2001 | *at Western Michigan | Kalamazoo, Mich. | | T, 3-3
Recap | Stats | Archived Audio |
| Fri | 01/19/2001 | *OHIO STATE | Joyce Center | | L, 5-3
Recap | Stats | Archived Audio | Live Box Score |
| Sat | 01/20/2001 | *OHIO STATE | Joyce Center | | T, 2-2
Recap | Stats | Archived Audio | Live Box Score |
| Tue | 01/23/2001 | *at Michigan | Ann Arbor, Mich. | | L, 9-0
Recap | Stats | Archived Audio |
| Sat | 01/27/2001 | *vs. Yale (at New Haven Coliseum) | New Haven, Conn. | | L, 8-2
Recap | Stats | Archived Audio |
| Sun | 01/28/2001 | *at Yale | New Haven, Conn. | | W, 4-3
Recap | Stats | Archived Audio |
| Fri | 02/02/2001 | *at Ohio State | Columbus, Ohio | | L, 5-2
Recap | Stats |
| Sat | 02/03/2001 | *at Ohio State | Columbus, Ohio | | L, 5-3
Recap | Stats | Archived Audio |
| Fri | 02/09/2001 | Bowling Green | Notre Dame, Ind. | | W, 3-2
Stats | Archived Audio | Live Box Score |
| Sat | 02/10/2001 | Bowling Green | Notre Dame, Ind. | | W, 5-3
Recap | Stats | Archived Audio | Live Box Score |
| Fri | 02/16/2001 | *at Michigan | Ann Arbor, Mich. | | T, 4-4
Recap | Stats | Archived Audio |
| Fri | 02/23/2001 | *at Alaska Fairbanks | Fairbanks, Alaska | | T, 4-4
Recap | Stats | Archived Audio |
| Sat | 02/24/2001 | *at Alaska Fairbanks | Fairbanks, Alaska | | W, 3-1
Recap | Stats | Archived Audio |
| Fri | 03/02/2001 | *at Western Michigan | Kalamazoo, Mich. | | W, 5-4
Recap | Stats | Archived Audio |
| Sat | 03/03/2001 | *WESTERN MICHIGAN | Joyce Center | | L, 7-2
Recap | Stats | Archived Audio | Live Box Score |
