| Day | Date | Opponent | Location | TV | Outcome/Time |
| Sun | 11/07/1999 | Ohio All-Stars (exhibition) | Notre Dame, Ind.
(Joyce Center) | | W, 94-85
Recap | Stats |
| Mon | 11/15/1999 | Sweden (exhibition) | Notre Dame, Ind.
(Joyce Center) | | W, 76-51
Recap | Stats | Archived Audio |
| Sat | 11/20/1999 | Toledo | Savage Hall | | W, 68-52
Recap | Stats | Archived Audio |
| Sat | 11/27/1999 | Illinois | Champaign, Ill. | | L, 77-67
Recap | Stats | Archived Audio |
| Wed | 12/01/1999 | Butler | Notre Dame, Ind.
(Joyce Center) | | W, 77-57
Recap | Stats | Archived Audio |
| Sat | 12/04/1999 | North Carolina | Richmond, Va.
(Wachovia Women's Invitational) | | W, 99-86
Recap | Stats | Archived Audio |
| Sun | 12/05/1999 | Liberty | Richmond, Va.
(Wachovia Women's Invitational) | | W, 85-68
Recap | Stats | Quotes | Archived Audio |
| Wed | 12/08/1999 | Purdue | West Lafayette, Ind. | | L, 71-61
Recap | Stats | Archived Audio |
| Sat | 12/11/1999 | Michigan State | Notre Dame, Ind.
(Joyce Center) | | W, 84-54
Recap | Stats | Archived Audio |
| Sun | 12/19/1999 | Florida Intl | Miami | | W, 68-62
Recap | Stats | Archived Audio |
| Mon | 12/27/1999 | USC | Notre Dame, Ind.
(Joyce Center) | | W, 74-59
Recap | Stats | Archived Audio |
| Wed | 12/29/1999 | Valparaiso | Notre Dame, Ind.
(Joyce Center) | | W, 88-63
Recap | Stats | Archived Audio |
| Sun | 01/02/2000 | Marquette | Notre Dame, Ind.
(Joyce Center) | | W, 75-60
Recap | Stats |
| Wed | 01/05/2000 | West Virginia* | Notre Dame, Ind.
(Joyce Center) | | W, 75-54
Recap | Stats | Archived Audio |
| Sat | 01/08/2000 | Georgetown* | Washington, D.C. | | W, 82-60
Recap | Stats | Archive Audio |
| Tue | 01/11/2000 | Seton Hall* | Notre Dame, Ind.
(Joyce Center) | | W, 80-52
Recap | Stats | Archive Audio |
| Sat | 01/15/2000 | Syracuse* | Notre Dame, Ind.
(Joyce Center) | | W, 71-56
Recap | Stats | Archived Audio |
| Tue | 01/18/2000 | Pittsburgh* | Pittsburgh | | W, 67-53
Recap | Stats | Archived Audio |
| Sat | 01/22/2000 | Miami* | Coral Gables, Fla. | | W, 76-54
Recap | Stats | Archived Audio |
| Wed | 01/26/2000 | St. John's* | Jamaica, N.Y. | | W, 69-49
Recap | Stats | Archived Audio |
| Sat | 01/29/2000 | Georgetown* | Notre Dame, Ind.
(Joyce Center) | | W, 87-56
Recap | Stats | Archived Audio |
| Tue | 02/01/2000 | Providence* | Providence, R.I. | | W, 90-60
Recap | Stats | Archived Audio |
| Sat | 02/05/2000 | Boston College* | Notre Dame, Ind.
(Joyce Center) | | W, 72-59
Recap | Stats | Archived Audio |
| Wed | 02/09/2000 | Pittsburgh* | Notre Dame, Ind.
(Joyce Center) | | W, 81-74
Recap | Stats | Archived Audio |
| Sat | 02/12/2000 | St. John's* | Notre Dame, Ind.
(Joyce Center) | | W, 94-51
Recap | Stats | Archived Audio |
| Wed | 02/16/2000 | Villanova* | Villanova, Pa. | | W, 70-52
Recap | Stats | Archived Audio |
| Sat | 02/19/2000 | Rutgers* | Piscataway, N.J. | | W, 78-74 (OT)
Recap | Stats |
| Tue | 02/22/2000 | Miami* | Notre Dame, Ind.
(Joyce Center) | | W, 83-68
Recap | Stats | Archived Audio |
| Sat | 02/26/2000 | Connecticut* | Storrs, Conn. | | L, 77-59
Recap | Stats | Archived Audio |
| Sun | 03/05/2000 | Miami (Big East Tournament) | Storrs, Conn. | | W, 67-52
Recap | Stats | Archived Audio |
| Mon | 03/06/2000 | Rutgers | Storrs, Conn.
(Big East Semis) | | L, 81-72, OT
Recap | Stats | Technical Difficulties prevented Internet Audio |
| Fri | 03/17/2000 | San Diego | South Bend, Ind.
(NCAA 1st Round) | | W, 87-61
Recap | Stats | Quotes | Notes | Archived Audio |
| Sun | 03/19/2000 | George Washington | South Bend
(NCAA 2nd Round) | | W, 95-60
Recap | Stats | Quotes | Notes | Archived Audio |
| Sat | 03/25/2000 | Texas Tech | Memphis, Tenn.
(NCAA Sweet 16) | espn2 | L, 69-65
Recap | Stats | Archived Audio |
